![]() ![]() Rat pups were exposed to a single-binge ethanol dose (6g/kg body weight) on PN6 to investigate brain tissue at PN26-30. The current study investigated whether there were any changes to the spines, synapses and mitochondria of the CA1 dendritic tree in the upper stratum radiatum following ethanol exposure. The axons from CA3 pyramidal neurons are an important input to the CA1 cells and it is likely that the synaptic complement of the CA1 apical dendritic tree will be altered to accommodate this imbalance. ![]() ![]() This has been previously investigated with cell count studies that found ethanol exposure during development significantly decreases the number of CA1 but not CA3 cells in the hippocampus. This suggests that although the brains of these subjects still contain the same basic circuitry, it appears to have been altered in some way that decreases performance. Children and animal models tested on these types of tasks are able to perform them but not to the same standard as controls. Exposure of the developing fetus to ethanol has numerous and wide-ranging effects including hippocampal damage resulting in difficulties with spatial learning and memory. ![]()
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